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葛健锋
发布人: liuxin 点击次数:3294次 发布时间:2014-05-04 16:40:00

 

 

 

 

 

      姓名:葛健锋
     职称:教授
     部门:材料学院

 

 

 

 

学历及学术经历: 1995年苏州大学化学教育专业毕业,1998年苏州大学有机化学专业获硕士学位,2003年苏州大学有机化学专业获博士学位,2005-2006年日本东北大学药学部博士后,2006-2008年日本星药科大学博士后。1998年起就职于苏州大学。在国内外核心化学期刊如J. Med. Chem., Org. Lett., Anal. Chem., Org. Biomol. Chem.,Sensor Actuat. B-Chem.等发表正式论文50多篇
 
研究领域:功能染料的设计与合成,功能染料的线性及非线性光学性能,近红外分子探针。
 
负责的科研项目:
D-π-D型分子的合成及光学性能的研究(2009-2011,负责人),江苏省高校自然科学基金;
有机材料、药物中间体的合成(2009年起,负责人),苏州大学-Synstar Jpn株式会社合作研究项目;
几类芳香稠杂环类共轭分子的三阶非线性光学性能的研究(2010-2012负责人),江苏省自然科学基金。
具有电荷双向流动能力的功能染料的合成及其三阶非线性光学性能(2013-2016,负责人),国家自然科学基金。
 
主要的教学奖项:
200312月,苏州大学第三届青年教师课堂教学竞赛二等奖;
20049月,苏州大学苏鑫奖教金;
200411月,苏州大学优秀教学成果奖二等奖;
 
主要的论文列表:
 (1)       Liu, X.-D.; Xu, Y.; Sun, R.*; Xu, Y.-J.; Lu, J.-M.*; Ge, J.-F.*, A coumarin-indole-based near-infrared ratiometric pH probe for intracellular fluorescence imaging. Analyst2013. DOI: 10.1039/c3an01033c.
(2)       Liu, W.; Sun, R.; Ge, J. F.*; Xu, Y. J.; Xu, Y.; Lu, J. M.*; Itoh, I.; Ihara, M.*, Reversible near-infrared pH probes based on benzo[a]phenoxazine. Anal. Chem.2013, 85, 7419-7425. DOI: 10.1021/ac4013539.
(3)       Liu, X. D.; Sun, R.; Ge, J. F.*; Xu, Y. J.; Xu, Y.; Lu, J. M.*, A squaraine-based red emission off-on chemosensor for biothiols and its application in living cells imaging. Org. Biomol. Chem.2013, 11, 4258-4264. DOI: 10.1039/c3ob40502h.
(4)       Liu, X.-D.; Sun, R.*; Xu, Y.; Xu, Y.-J.; Ge, J.-F.*; Lu, J.-M.*, A benzoxazine–hemicyanine based probe for the colorimetric and ratiometric detection of biothiols. Sensor Actuat. B-Chem.2013, 178, 525-531. DOI: 10.1016/j.snb.2012.12.108.
(5)       Sun, R.; Yan, B.-L.; Ge, J.-F.*; Xu, Q.-f.; Li, N.-J.; Wu, X.-Z.; Song, Y.-L.; Lu, J.-M.*, Third-order nonlinear optical properties of unsymmetric pentamethine cyanine dyes possessing benzoxazolyl and benzothiazolyl groups. Dyes Pigments.2013, 96, 189-195. DOI: 10.1016/j.dyepig.2012.07.007.
(6)       Zhang, Q.-Q.; Yang, B.-X.; Sun, R.; Ge, J.-F.*; Xu, Y.-J.; Li, N.-J.; Lu, J.-M.*, A near-infrared phenoxazinium-based fluorescent probe for zinc ions and its imaging in living cells. Sensor Actuat. B-Chem.2012, 171-172, 1001-1006. DOI: 10.1016/j.snb.2012.06.017.
(7)       Shi, Q.-Q.; Sun, R.; Ge, J.-F.*; Xu, Q.-F.; Li, N.-J.; Lu, J.-M.*, A comparative study of symmetrical and unsymmetrical trimethine cyanine dyes bearing benzoxazolyl and benzothiazolyl groups. Dyes Pigments.2012, 93, 1506-1511. DOI: 10.1016/j.dyepig.2011.11.001.
(8)       Ge, J.-F.*; Zhang, Q.-Q.; Lu, J.-M.*; Kaiser, M.; Wittlin, S.; Brun, R.; Ihara, M.*, Synthesis of cyanine dyes and investigation of their in vitro antiprotozoal activities. MedChemComm2012, 3, 1435-1442. DOI: 10.1039/c2md20136d.
(9)       Yang, X.-B.; Yang, B.-X.; Ge, J.-F.*; Xu, Y.-J.; Xu, Q.-F.; Liang, J.; Lu, J.-M.*, Benzo[a]phenoxazinium-based red-emitting chemosensor for zinc ions in biological media. Org. Lett.2011, 13, 2710-2713. DOI: 10.1021/ol2008022.
(10)   Liu, B.-Q.; Sun, R.; Ge, J.-F.*; Li, N.-J.; Shi, X.-L.; Qiu, L.-H.*; Lu, J.-M., The synthesis and third-order nonlinear optical properties of resonance benzo[a]phenoxazinium salts. Dyes Pigments.2011, 88, 50-56. DOI: 10.1016/j.dyepig.2010.04.014.
(11)   Zhang, Q.-Q.; Ge, J.-F.*; Xu, Q.-F.; Yang, X.-B.; Cao, X.-Q.; Li, N.-J.; Lu, J.-M.*, A selective, sensitive probe for mercury(II) ions based on oxazine-thione. Tetrahedron Lett.2011, 52, 595-597. DOI: 10.1016/j.tetlet.2010.11.130.
(12)   Yang, X.-B.; Ge, J.-F.*; Xu, Q.-F.; Zhu, X.-L.; Li, N.-J.; Gu, H.-W.; Lu, J.-M.*, Selective ratiometric detection of Hg2+ in pure water using a phenoxazinium-based probe. Tetrahedron Lett.2011, 52, 2492-2495. DOI: 10.1016/j.tetlet.2011.03.013.
(13)   Ge, J.-F.; Lu, Y.-T.; Xu, Q.-F.; Liu, W.; Li, N.-J.; Sun, R.*; Song, Y.-L.; Lu, J.-M.*, Third-order nonlinear optical properties of a new type of D-π-D unsymmetrical phenoxazinium chloride with resonance structures. Chem. Phys.2011, 382, 74-79. DOI: 10.1016/j.chemphys.2011.02.013.
(14)   Shi, X.-L.; Ge, J.-F.*; Liu, B.-Q.; Kaiser, M.; Wittlin, S.; Brun, R.; Ihara, M.*, Synthesis and in vitro antiprotozoal activities of 5-phenyliminobenzo[a]phenoxazine derivatives. Bioorg. Med. Chem. Lett.2011, 21, 5804-5807. DOI: 10.1016/j.bmcl.2011.07.112.
(15)   Lu, Y.-T.; Ge, J.-F.*; Xu, Q.-F.; Yang, Y.; Li, N.-J.; Sun, R.; Xia, X.-W.; Song, Y.-L.; Lu, J.-M.*, Third-order nonlinear optical properties of the phenothiazinium chlorides at 532 nm. Dyes Pigments.2011, 89, 70-75. DOI: 10.1016/j.dyepig.2010.09.006.
(16)   Ge, J.-F.; Arai, C.; Yang, M.; Bakar Md, A.; Lu, J.; Ismail, N. S. M.; Wittlin, S.; Kaiser, M.; Brun, R.; Charman, S. A.; Nguyen, T.; Morizzi, J.; Itoh, I.; Ihara, M., Discovery of novel benzo[a]phenoxazine SSJ-183 as a drug candidate for malaria. ACS Med. Chem. Lett.2010, 1, 360-364. DOI: 10.1021/ml100120a.
(17)   Ge, J.-F.; Arai, C.; Kaiser, M.; Wittlin, S.; Brun, R.; Ihara, M., Synthesis and in vitro antiprotozoal activities of water-soluble, inexpensive 3,7-bis(dialkylamino)phenoxazin-5-ium derivatives. J. Med. Chem.2008, 51, 3654-3658. DOI: 10.1021/jm8003619.
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